Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections
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چکیده
منابع مشابه
Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections.
During an infection, malaria parasites compete for limited amounts of food and enemy-free space. Competition affects parasite growth rate, transmission and virulence, and is thus important for parasite evolution. Much evolutionary theory assumes that virulent clones outgrow avirulent ones, favouring the evolution of higher virulence. We infected laboratory mice with a mixture of two Plasmodium ...
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Explaining parasite virulence is a great challenge for evolutionary biology. Intuitively, parasites that depend on their hosts for their survival should be benign to their hosts, yet many parasites cause harm. One explanation for this is that within-host competition favors virulence, with more virulent strains having a competitive advantage in genetically diverse infections. This idea, which is...
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Humans and animals often become coinfected with pathogen strains that differ in virulence. The ensuing interaction between these strains can, in theory, be a major determinant of the direction of selection on virulence genes in pathogen populations. Many mathematical analyses of this assume that virulent pathogen lineages have a competitive advantage within coinfected hosts and thus predict tha...
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We consider a discrete time model of semelparous biennial population dynamics. Interactions between individuals are modelled with the aid of an "environmental" variable I. The impact on and the sensitivity to the environmental condition is age specific. The main result is that competitive exclusion between the year classes is possible as is their coexistence. For moderate values of the basic re...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of London. Series B: Biological Sciences
سال: 2004
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.2004.2695